Tag: Acromegaly
HPS Axis Pirouette
March 15, 2018To soften the pressure of the increasingly dominant genetic profiles for greater human height, humanity at some point may opt to interfere in the cell signaling pathways that induce growth. One such pathway, the hypothalamic–pituitary axis, includes the secretion of growth hormone (GH) into the circulation and the subsequent stimulation of insulin-like…
Pegvisomant
November 19, 2012Pegvisomant (tradename Somavert) is a genetically engineered analogue of the human growth hormone (GH) that stops unnaturally vigorous growth in patients with acromegaly. It works as a GH receptor antagonist and blocks or dampens agonist-mediated responses by binding to growth hormone receptors on cell surfaces. Pegvisomant is used…
Universal Height Dysphoria
July 8, 2012Perhaps humanity’s willingness to accept the damaging consequences of increasing human height is the the result of a universal case of height dysphoria. Height dysphoria is a mental disorder that leads to excessive concern about and preoccupation with a perceived defect of physical size. Most often this means the…
