Tag GH

HPS Axis Pirouette

To soften the pressure of the increasingly dominant genetic profiles for greater human height, humanity at some point may opt to interfere in the cell signaling pathways that induce growth. One such pathway, the hypothalamic–pituitary axis, includes the secretion of growth hormone (GH) into the circulation and the subsequent stimulation of insulin-like growth factor 1 (IGF-1) production by GH in tissues such as the liver. The [...]

Medicalizing Short Stature

The US market for growth hormone is estimated at 22 billion dollars. But it wasn’t always such an enormous market. Two growth hormone producers, Eli Lilly and Genentech, have worked hard to medicalize short stature and convince children and their parents that being short is a disease rather than a natural variation in human height. At first the administration [...]