Tag growth hormone

HPS Axis Pirouette

To soften the pressure of the increasingly dominant genetic profiles for greater human height, humanity at some point may opt to interfere in the cell signaling pathways that induce growth. One such pathway, the hypothalamic–pituitary axis, includes the secretion of growth hormone (GH) into the circulation and the subsequent stimulation of insulin-like growth factor 1 (IGF-1) production by GH in tissues such as the liver. The [...]

The Turkish Seat

The Turkish Seat, also known as the Sella Turcica, forms a bony throne for one of the most important protagonists in our ambitious desire for a smaller human species: the pituitary gland. It is here within the deepest part of the cavity (called the hypophysial fossa) above the Turkish Seat that this small gland, the size of [...]

Uppers & Downers

Hormones play a key role in growth as the chemical mediators with which the growth process is stimulated, or slowed down. Most hormones are controlled by a negative feedback inhibition loop. If we are to shrink the human species manipulation of this loop may represent one of the possible approaches.
Negative feedback was first implemented in mechanics [...]