Category Endocrinology

The Larons

People living in remote villages in Ecuador have a genetic mutation that may just hold the key to shrinking mankind. The villagers have a rare condition known as Laron syndrome. They are generally less than three and a half feet tall, they are proportional, and interestingly, they are also almost free of cancer and diabetes. The Laron People (we […]

Tall Risk

A study of 1,3 million women published in The Lancet Oncology finds that tall women are more likely to develop cancer. The researchers looked at the incidence of 17 cancer types, from breast cancer to leukemia, in a long-term health study across socio-economic levels. Cancer risk rose 16% with every added 10 centimeters (4 inches) […]

Of Snell Mice and Men

Mice and men display striking genetic similarities in hormone dependent growth disturbances. If a mouse responds in a certain way to a genetic mutation, chances are that a human will respond in similar fashion. The first dwarf mouse was discovered by Nobel Prize winner George Snell in 1929. Later during the sixties research on the Snell mouse […]


It seems as if nature itself is already investigating ways to counter hypergrowth, overpopulation and overconsumption. It’s creating perfectly proportioned, but small, human beings. Pituitary dwarfism, also known as Dwarfism of Sindh, is a form of growth absense where all parts of the body grow equally slow. At the core of this proportionate shrinking is a role for GHRHR, Growth […]

Small & Smart

There is an understandable fear that if we shrink the human body we might lose part of our brain capacity. With a projected head size of only 6 x 4,5 centimeters tall it’s an obvious concern. One of the possible solutions we’ve reported on in a previous post, is outsourcing most of our brain capacity […]

Dwarfism of Sindh

Donald Platt points out an interesting case of dwarfism in Pakistan. In 1994, an article appeared in a Pakistan newspaper, describing the existence of a cluster of familial dwarfism in two remote villages in the lower Indus valley.  The subjects were perfectly proportioned and in good physical health displaying little or none of the negative […]

Uppers & Downers

Hormones play a key role in growth as the chemical mediators with which the growth process is stimulated, or slowed down. Most hormones are controlled by a negative feedback inhibition loop. If we are to shrink the human species manipulation of this loop may represent one of the possible approaches. Negative feedback was first implemented in […]