Category: Endocrinology

GH Resistance

December 26, 2011 By arne hendriks 1

Stature is a highly heritable trait controlled by genetic and environmental factors. Pygmies display a remarkable and inspiring resistance to growth hormone (GH). African Pygmies represent a paradigmatic example of non-disease-related idiopathic short stature. Even if large quantities of GH are administered to them, they simply ignore…

The Larons

November 9, 2011 By arne hendriks 2

People living in remote villages in Ecuador have a genetic mutation that may just hold the key to shrinking mankind. The villagers have a rare condition known as Laron syndrome. They are generally less than three and a half feet tall, they are proportional, and interestingly, they are…

Tall Risk

August 3, 2011 By arne hendriks 2

A study of 1,3 million women published in The Lancet Oncology finds that tall women are more likely to develop cancer. The researchers looked at the incidence of 17 cancer types, from breast cancer to leukemia, in a long-term health study across socio-economic levels. Cancer…

Of Snell Mice and Men

April 17, 2011 By arne hendriks 1

Mice and men display striking genetic similarities in hormone dependent growth disturbances. If a mouse responds in a certain way to a genetic mutation, chances are that a human will respond in similar fashion. The first dwarf mouse was discovered by Nobel Prize winner George Snell in…

GHRHR

February 11, 2011 By arne hendriks 0

It seems as if nature itself is already investigating ways to counter hypergrowth, overpopulation and overconsumption. It’s creating perfectly proportioned, but small, human beings. Pituitary dwarfism, also known as Dwarfism of Sindh, is a form of growth absense where all parts of the body grow equally slow. At…

Small & Smart

January 29, 2011 By arne hendriks 1

There is an understandable fear that if we shrink the human body we might lose part of our brain capacity. With a projected head size of only 6 x 4,5 centimeters tall it’s an obvious concern. One of the possible solutions we’ve reported on in…

Dwarfism of Sindh

January 18, 2011 By arne hendriks 0

Donald Platt points out an interesting case of dwarfism in Pakistan. In 1994, an article appeared in a Pakistan newspaper, describing the existence of a cluster of familial dwarfism in two remote villages in the lower Indus valley.  The subjects were perfectly proportioned and in…

Uppers & Downers

December 1, 2010 By arne hendriks Off

Hormones play a key role in growth as the chemical mediators with which the growth process is stimulated, or slowed down. Most hormones are controlled by a negative feedback inhibition loop. If we are to shrink the human species manipulation of this loop may represent one…