Guangzhou Reversal Room

The Incredible Shrinking Man was invited by the Guangzhou Triennial 2018, curated by Angelique Spaninks, Zhang Ga and Philip Ziegler, to resurrect one of its favourite shrink experiences: the Ames room. An Ames room allows people to visually experience a shift in body size by means of optical distortion. We are generally keenly aware of our height in relation to others and changing the perception of body size can be a powerful reminder of its role in establishing our relationships and behaviour.

Unfortunately height plays a role in the creation of a subconscious hierarchy where greater height is valued over smallness: something The Incredible Shrinking Man regrets and wants to change. The Ames room allows for a momentarily release from this ‘fixed’ position and to redefine our relationship through resizing ourselves in relation to the other. Not surprisingly, earlier try-outs showed that short people want to experience how it feels to be taller, while the tall giggled at the experience of being short. Although the room is not yet able to reverse the overall dominant desire for greater height it does initiate awareness of the subconscious forces in play. Those forces include the default response of most short people to allow tall people to be more present, to take control, to take up more prestigious positions in society, to be paid better, to have more offspring. Greater awareness of these ‘free’ privileges may lead to a more equal playing field as the small modify their behaviour, while the tall come to understand that some of their achievements were not necessarily achieved only by merit but because it is easier for them to succeed. While these are the same arguments that make most people want to be tall, awareness and mutual understanding can increase space for the short to take center stage, and in doing so create greater appreciation of the beauty and power of the small.

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Hallmarks of Malignant Growth: Avoiding Immune Destruction

In trying to understand what makes the idea of continuous growth so powerful (despite clear evidence that it is a harmful concept) The Incredible Shrinking Man turned to cancer research to learn where healthy growth turns malignant. Although cancer is a very complex phenomenon the seminal paper “ The hallmarks of cancer” managed to simplify its underlying process to ten common traits that every single cancer shares to facilitate the transformation from a normal cell to a cancer cell. Published by Robert Weinberg and Douglas Hanahan in 2000, with an updated version in 2013, the paper functions as a guide and lens to learn what the underlying principles of growth are. And what to do about it when things go wrong. Like in our growth-obsessed economy perhaps.

The tenth hallmark of cancer is it’s ability to avoid immune destruction. The immune system is intimately involved in the entire process of cancer progression, both in tumor eradication as in tumor immune potentiation. 1. The first escape mechanism is simply continued mutation and selection within the growing tumor.  When the immune system recognises an abnormal cell it moves in to kill the abnormal cell through T cells, natural killer cells (NK) or macrophages. Unfortunately, the same process can also create tumor immune potentiation (immune-editing). If the tumor contains cells that are able to survive the onslaught then these cells will eventually start to proliferate and make the immune system less effective. 2. Cell’s wear their health on their sleeves in the form of antigens. These are pieces of protein that the cell presents on its surface and that display what is going on inside the cell. The immune system check if the antigens are representative of a healthy cell. If not it kills the cell. The second mechanism is the under-expression of  MHC1 so that the cell doesn’t display its abnormal antigens. Recognition of cancerous cells can be difficult since cancer cells are in fact a modified self. Still, both the innate and the adaptive immune system are quite efficient at suppressing most abnormal cell growth, inappropriate metabolism and inappropriate movement. Cancer cells also present pieces of information about its intercellular processes on their membrane (through MHC1) that give the immune system clues that it is abnormal. MHC1 is the display case. However, if MHC1 levels become too low natural killer cells move in and attack the cell. A precise expression of MHC1 that is low enough but not too low, will help certain cancer cells survive. 3. The third evasive strategy is the tumor’s expression of TGF-Beta while at the same time down-regulating TFG-Beta receptors on its surface. TGF-Beta induces apoptosis in surrounding cells (they have the receptors that cancer does not) while encouraging the formation of new blood vessels. In short, by expressing TGF-Beta the tumor creates space for itself by killing competing cells while making sure it gets resources to grow. 4. The fourth strategy is immune suppression through regulatory cells. The immune system needs to be regulated not to attack self cells. Cancer hijacks the principle by expressing regulatory proteins (Treg. MDSC) that suppress the immune system from acting upon the tumor. 5. The fifth strategy is that cancer cells change their metabolism by up-regulating Glycolysis within the hypoxic micro-environment of the tumor. In doing so they take nutrients (glucose) away from the immune cells and lower surrounding pH levels. Lower pH levels stops maturation of T cells and MHC1. So an important part of cancer’s defence against the immune system is to make simple changes in the biochemical and nutritional environment that benefit tumorgenesis.

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Implosion Fabrication


It’s not quite the Dehnel phenomenon but implosion fabrication does allow for a different perspective on shape shifting, size and shrinking and may just add a piece to the puzzle of achieving a smaller size for that bloated hydro-species by the name of Homo sapiens.

Researchers at MIT created a technique to shrink 3D printed structures to the nanoscale while attaching various functional particles like gold or DNA to a super absorbent polymer hydrogel  scaffold . By dehydrating the scaffold the printed structures reduced a 10-fold in size in all dimensions (a 1000 fold in mass). Senior researcher Edward Boyden and his students further developed a technique known as expansion microscopy,  which involves embedding tissue into a hydrogel and then expanding it, allowing for high resolution imaging with a regular microscope. By reversing this process, the researchers found that they could create large-scale objects embedded in expanded hydrogels and then shrink them to the nanoscale, an approach that they call “implosion fabrication.” Using two-photon microscopy, which allows for precise targeting of points deep within a structure, the researchers attach fluorescein molecules to specific locations within the gel. The fluorescein molecules act as anchors that can bind to other types of molecules that the researchers add. “It’s a bit like film photography — a latent image is formed by exposing a sensitive material in a gel to light. Then, you can develop that latent image into a real image by attaching another material, silver, afterwards.” Once the desired molecules are attached in the right locations, the researchers shrink the entire structure by adding an acid. Currently, they can create objects that are around 1 cubic millimeter, patterned with a resolution of 50 nanometers.

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Hallmarks of Malignant Growth: Deregulating Energy Metabolism

In trying to understand what makes the idea of continuous growth so powerful (despite clear evidence that it is a harmful concept) The Incredible Shrinking Man turned to cancer research to learn where healthy growth turns malignant. Although cancer is a very complex phenomenon the seminal paper “ The hallmarks of cancer” managed to simplify its underlying process to ten common traits that every single cancer shares to facilitate the transformation from a normal cell to a cancer cell. Published by Robert Weinberg and Douglas Hanahan in 2000, with an updated version in 2013, the paper functions as a guide and lens to learn what the underlying principles of growth are. And what to do about it when things go wrong. Like in our growth-obsessed economy perhaps.

The ninth hallmark is cancer’s ability to reprogram the cell’s energy metabolism to cater for its enormous resource needs. Everything a cell does needs energy obtained from breaking down nutrients through respiration, a process of metabolic reactions. This energy is then stored as adenosine triphosphate (ATP), the energy currency of the cell. Normal cells, under normal conditions, undergo aerobic respiration, a metabolic pathway that requires oxygen. Cells break down glucose into pyruvate (glycolysis), to eventually form ATP, while releasing carbon dioxide as a waste product. When there isn’t enough oxygen, cells switch to anaerobic respiration where cells break down glucose into pyruvate and construct ATP but produce lactic acid instead of carbon dioxide. Aerobic respiration produces far more ATP molecules, 32 per molecule of glucose, than anaerobic respiration, which produces a mere two. Still cancer prefers the latter because of two reasons: 1. Although cancer cells produce far less ATP per molecule of glucose, they produce it almost a hundred times faster than normal cells. Cancer cells also actively produce more glucose transporters on their cell surface membranes, so more glucose is brought inside the cell. The benefits of speedy ATP production outweigh the costs associated with inefficient glucose breakdown. 2. Cancer cells undergoing aerobic glycolysis also produce many intermediate biosynthetic precursors used as building blocks by the rapidly dividing cells. In healthy cells the ability to grow and divide rapidly is useful in the context of wound healing and immune responses. When an immune response is required, immune cells massively increase their glucose uptake, switch from metabolising glucose through normal respiration to aerobic glycolysis, and ramp up the biosynthesis of proteins, lipids and DNA. Therefore, there is a strong evolutionary basis for rapid cell division and faster growth despite the inefficient use of glucose in the process. Cancer cells hijack this metabolic switch in order to fuel their own uncontrolled growth.

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The Cell Cycle: Mitogen

The Cell Cycle investigates the mechanisms and substances that regulate cell division and growth. The process of deciding to divide, or not, is a highly regulated interplay of messages and receptors reporting on the state of the environment and the state of the cell. While contemporary conditions have prompted most animal species to initiate an evolutionary process of shrinkage, humans continue to grow taller. Twenty-first century Homo sapiens is the tallest human species of all time. Our contemporary cell climate is one of constant high biological and cultural pressure to proliferate, to expand, divide and grow bigger. It is a situation of biological confusion because of an ill-informed and misdirected cultural environment. The global human body is manipulated into expressing growth as the best strategy for longterm survival while in fact shrinking would be the more rational and sustainable choice.

The divisive processes within the cell cycle that express this confused situation are initiated by mitogens, the signals involved in giving the green light to go ahead at a critical point in the cell cycle. A mitogen is an intermediate agent between the cell and its environment that encourages, if conditions seem favourable, to commence cell division. Mitogens act primarily by influencing a set of proteins which are involved in the restriction of progression through the cell cycle, especially checkpoint G1. Before clearing the checkpoint in G1 the cell can still abort the process of division. After G1 is passed growth abortion becomes much more complicated as the cell is able to continue autonomously without the need for external signals. If mitogens are over-expressed they may cause growth that is unnecessary or even damaging, like in cancer as well as the irrational increase in human height. Both symptoms are defined by a lack of, or failure of, control in the cell cycle. Mitogens can cause the cell cycle to move forward when in fact it shouldn’t. In normal cells this would be corrected by mechanisms designed to prevent the uncontrolled growth of cells, internal or external. Current signalling in and around the cell has allowed the human species to grow to an unprecedented size that poorly reflects global environmental conditions. Pressure on our resources has never been greater. Unless we study mitogen from the position of a desire of non-proliferation we will never understand how global height can be decreased.

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Calimero Complex

In the Low Countries the Calimero Complex refers to people, organisations or countries that feel they’re under-appreciated because of their small size. The name given to the complex refers to the lead character Calimero in an Italian animated cartoon series featured in the early 70’s on Dutch and Belgian public tv. Calimero is a small black chick in a family of only yellow chicks. He wears half of his egg shell still on his head. His small size often makes him cry out: “They are big and I is small, and that’s not fair, oh no!”. Rather than the Napoleon Complex or other forms of supposed low self-esteem because of size, the Calimero Complex is understood to be a more passive state of feeling sorry for oneself while at the same time blaming others for your own shortcomings. It’s a presumptuous definition, to say the least.

The Dutch are the tallest people in the world. It is therefor interesting to note that the use of the term Calimero Complex is used exclusively in the Low Countries. After all it is easier to make such size-related judgements of a specific type of behaviour or character from the perspective of (mistaken) presumed superiority. Saying somebody has a Calimero Complex says just as much, or more, about the supposedly privileged person saying it.

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D(r)egrowth

What does it mean when your spelling control keeps changing the word degrowth into the word regrowth? How obsessed with growth must a society be when decades after the word degrowth was introduced to inspire a paradigm shift towards the destructive idea of continuous economic growth, our vocabulary still does not except it, and not only presumes it to be a mistake but suggests us to embrace the correct ideology of regrowth? Are our ‘intelligent’ economy-bound algorithms not allowing us to think in terms other than more?

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Hallmarks of Malignant Growth: Tumor-promoting Inflammation

In trying to understand what makes the idea of continuous growth so powerful (despite clear evidence that it is a harmful concept) The Incredible Shrinking Man turned to cancer research to learn where healthy growth turns malignant. Although cancer is a very complex phenomenon the seminal paper “ The hallmarks of cancer” managed to simplify its underlying process to ten common traits that every single cancer shares to facilitate the transformation from a normal cell to a cancer cell. Published by Robert Weinberg and Douglas Hanahan in 2000, with an updated version in 2013, the paper functions as a guide and lens to learn what the underlying principles of growth are. And what to do about it when things go wrong. Like in our growth-obsessed economy perhaps.

The eighth hallmark of cancer is that it can corrupt and recruit the immune system to help it survive, grow, migrate and start colonies. This process is enabled in a climate of constant inflammation. Normally, inflammation is how tissue responds to injury, for instance during the healing of a wound. It is local and protective. The function of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and initiate tissue repair. However, if the inflammation-causing agent persists for a prolonged period of time, the body’s response to it becomes a chronic inflammation, which increases cancer risk. There are many similarities between a cancerous tumor and a healing wound. The ‘healing’ processes are controlled by growth factors and signaling molecules. The inflammatory response, which involves the activation of the NF-beta-B pathway, activates a wide range of genes involved with providing exactly what cancer needs to survive, grow and migrate. Just as the immune cells gather near a site of injury to secrete growth factors to begin tissue repair, tumors can also surround themselves with immune cells that secrete these same growth factors to promote their uncontrolled cell growth. Various types of immune cells are involved but the main culprits are known as Tumor Associated Macrophages (TAMs). In some instances they comprise as much as 50% of the tumor mass. TAM’s assist cancer cells in bypassing some of the anti-cancer defense mechanisms as described in previous posts: 1. They secrete and provide growth factors to the tumor. 2. They promote angiogenesis by secreting VEGF and PDGF in the oxygen deprived regions of the tumor. 3. They suppress the adaptive immune system by secreting immunosuppressive molecules, or by attracting other inactive immune cells. 4. They degrade the extra cellular matrix by expressing the enzym metalloproteases, thus allowing for metastasis.

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Amplexus Tantra

It may seem farfetched and even a little awkward to discuss a frog’s preferred sexual position as part of a strategy to shrink. However, to change humanity’s irrational desire for bigger towards a much wiser desire for smaller we must invest as much in alternative fantasies and imaginative storytelling as in the instantly practical.

In the light of the dominant universal female preference for taller males, the dominant amplexus technique seen in frogs, toads, newts and horse crabs opens up a window of tantric opportunity. During amplexus, the female carries the male around on her back. To make sure he doesn’t fall off different species of frogs have different preferred places to hold onto. Sometimes it is the back, sometimes the legs and in some cases the head. All this hanging around may not seem particularly friendly towards the female frog, and perhaps it wouldn’t be if it were not for her preference for small males. The smaller the male, the more stamina and the more pleasant it is for the female to perform her side of the act. Which is all the better since the whole thing can last many hours.

But most importantly,  the smaller the male the smaller the offspring.

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Micro-Livestock’s Short Shadow

Livestock’s Long Shadow: Environmental Issues and Options, a 2006 report released by the Food and Agriculture Organisation, assesses the impact of the livestock sector on environmental challenges, along with potential technical and policy approaches to mitigation. The livestock sector poses serious challenges to the environment at every scale from local to global. According to senior U.N. Food and Agriculture Organization official Dr. Henning Steinfeld the meat industry is “one of the most significant contributors to today’s most serious environmental problems” and “urgent action is required to remedy the situation.” The report evaluates that livestock are responsible for 1/5th of global greenhouse gas emissions, arising from feed production, fertilizer production, deforestation, feed and animal products transport, soil erosion in pastures and feed crops, enteric fermentation and methane and nitrous oxide emissions from manure. If man shrinks his needs shrink. Physically downsizing existing livestock or moving towards smaller alternative livestock options will have significant consequences in battling meat’s negative contribution to environmental challenges.

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